G protein-coupled purinergic nucleotide receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the G protein-coupled purinergic nucleotide receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR34, MAN1C1, and MAPKAPK5, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR34 grouped by G protein-coupled purinergic nucleotide receptor signaling pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GPR34 →	-0.406	-1.642	.008	.005	2	13
CNS	MAN1C1 →	-0.297	-1.043	<.001	<.001	3	6
BLOOD_Lymphoma	MAPKAPK5 →	-0.345	-1.950	<.001	<.001	3	6
LARGE_INTESTINE	CDKAL1 →	-0.199	-1.028	.005	.002	3	5
LARGE_INTESTINE	FRMPD2 →	+0.144	+1.232	.003	<.001	3	5
LARGE_INTESTINE	RRH →	-0.137	-1.011	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR34 by G protein-coupled purinergic nucleotide receptor signaling pathway activity — BONE

Explore this box plot interactively →