Non-canonical Wnt signaling pathway

Across TCGA patient cohorts, RNA activity of the Non-canonical Wnt signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTHRC1, EFEMP2, and ISLR, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-canonical Wnt signaling pathway activity versus CTHRC1 in OV (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CTHRC1 →	+1.035	+0.054	<.001	<.001	3	9
CCRCC	EFEMP2 →	+0.726	+0.026	<.001	<.001	3	9
OV	ISLR →	+0.770	+0.044	.001	.004	3	9
OV	PCOLCE →	+0.665	+0.038	<.001	<.001	3	9
UCEC	RSU1 →	+0.446	+0.053	.003	.007	3	8
OV	SERPINF1 →	+0.705	+0.044	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035567 vs CTHRC1 — OV

Explore this scatter interactively →