Non-canonical Wnt signaling pathway

Across TCGA patient cohorts, RNA activity of the Non-canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF436, FRMD6, and FZD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-canonical Wnt signaling pathway activity versus ZNF436 in LSCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF436 →	+0.457	+0.401	<.001	<.001	3	6
OV	FRMD6 →	+0.779	+0.295	<.001	<.001	3	5
OV	FZD1 →	+1.096	+0.374	<.001	<.001	3	5
OV	C1QTNF3 →	+1.794	+0.471	<.001	<.001	3	5
LSCC	NRIP3 →	+0.687	+0.332	<.001	.002	2	5
UCEC	CCDC150 →	-0.680	-0.428	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035567 vs ZNF436 — LSCC

Explore this scatter interactively →