Non-canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Non-canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSAD1, B4GALT5, and ALPP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RSAD1 grouped by Non-canonical Wnt signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RSAD1 →	-0.812	-0.354	.001	<.001	3	4
BREAST	B4GALT5 →	+0.934	+0.359	.009	.003	3	4
BREAST	ALPP →	+1.903	+0.319	.001	.002	3	4
URINARY_TRACT	ZNF416 →	+0.494	+0.328	.007	.006	3	4
CNS	UFL1 →	-0.363	-0.312	.009	.009	3	3
CNS	SLC39A6 →	-0.620	-0.437	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RSAD1 by Non-canonical Wnt signaling pathway activity — BREAST

Explore this box plot interactively →