Non-canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Non-canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD14B, PPM1M, and GRHL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-canonical Wnt signaling pathway activity versus ABHD14B in LIVER (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ABHD14B →	+1.229	+0.391	.004	.005	3	5
LIVER	PPM1M →	+1.532	+0.458	<.001	<.001	3	5
LUNG_NSCLC_LUSC	GRHL1 →	-1.682	-0.293	.008	.008	3	5
OESOPHAGUS	ALDH8A1 →	+0.219	+0.286	.002	<.001	3	5
LUNG_NSCLC_LUSC	RTL8C →	+1.452	+0.337	.005	.001	3	4
UPPER_AERODIGESTIVE_TRACT	PSMB10 →	+1.632	+0.291	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035567 vs ABHD14B — LIVER

Explore this scatter interactively →