Regulation of SNARE complex assembly

Across TCGA patient cohorts, RNA activity of the Regulation of SNARE complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RAB3GAP1_S537, STRBP, and SRCIN1_S866, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of SNARE complex assembly activity versus RAB3GAP1_S537 in PDAC (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RAB3GAP1_S537 →	-0.433	-0.037	.001	.006	3	4
COAD	STRBP →	+0.228	+0.026	.001	.001	3	4
LUAD	SRCIN1_S866 →	+0.630	+0.046	.001	.001	3	4
LSCC	TP53BP2_S720 →	-0.665	-0.053	.007	<.001	3	4
LSCC	CHD4_T1653 →	-0.287	-0.043	.004	<.001	3	4
OV	AHNAK_S256 →	-0.865	-0.047	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035542 vs RAB3GAP1_S537 — PDAC

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