Regulation of SNARE complex assembly

Across TCGA patient cohorts, RNA activity of the Regulation of SNARE complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERH, TNS2, and MYRF-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of SNARE complex assembly activity versus ERH in GBM (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ERH →	-0.375	-0.116	<.001	.004	3	3
BRCA	TNS2 →	+0.553	+0.109	.004	.001	3	3
GBM	MYRF-AS1 →	+0.532	+0.133	.003	.005	3	3
GBM	MYBPC3 →	+0.219	+0.122	.006	.007	3	3
GBM	NEK3 →	+0.338	+0.116	.002	.002	2	4
BRCA	TAMALIN →	+0.608	+0.145	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035542 vs ERH — GBM

Explore this scatter interactively →