Regulation of SNARE complex assembly

Across TCGA cell cohorts, RNA activity of the Regulation of SNARE complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP16, AKAP12, and PPM1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP16 grouped by Regulation of SNARE complex assembly-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DUSP16 →	-1.079	-1.072	<.001	<.001	3	3
LARGE_INTESTINE	AKAP12 →	+3.043	+1.120	.004	<.001	3	3
LARGE_INTESTINE	PPM1B →	-0.731	-1.124	.003	.001	3	3
LARGE_INTESTINE	MECOM →	-1.668	-0.794	.008	.007	3	3
SOFT_TISSUE	ZNF296 →	+1.411	+0.316	.001	<.001	2	4
PANCREAS	LRRC57 →	+0.528	+1.103	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP16 by Regulation of SNARE complex assembly activity — LARGE_INTESTINE

Explore this box plot interactively →