Protein K29-linked deubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K29-linked deubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are USP13, TEX10, and PMM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K29-linked deubiquitination activity versus USP13 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	USP13 →	+0.487	+0.087	<.001	<.001	3	7
LSCC	TEX10 →	+0.251	+0.054	<.001	<.001	3	6
UCEC	PMM2 →	-0.244	-0.066	.002	.003	3	6
LSCC	KIF13B →	-0.198	-0.043	.001	.003	3	6
LSCC	YY1AP1_S724 →	+0.538	+0.068	<.001	.001	3	5
LSCC	HDAC2 →	+0.282	+0.062	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035523 vs USP13 — LSCC

Explore this scatter interactively →