Negative regulation of myosin-light-chain-phosphatase activity

pathway activity — cross-omics
GO:0035509Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of myosin-light-chain-phosphatase activity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ROCK1_S1341, ROCK2_S1374, and PNISR_S290, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVROCK1_S1341 →+0.868+0.370<.001<.00135
OVROCK2_S1374 →+1.221+0.341<.001<.00135
OVPNISR_S290 →-1.039-0.322<.001.00234
GBMCDK5RAP1 →-0.475-0.733<.001.00333
GBMF11R_S296 →+0.478+0.846.001<.00124
OVFMNL2_S188 →+1.460+0.677<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration