SNARE complex assembly

Across TCGA patient cohorts, RNA activity of the SNARE complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRPX, ARRB2, and MFSD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, SNARE complex assembly activity versus SRPX in HNSC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SRPX →	+1.077	+0.145	.001	.004	3	3
GBM	ARRB2 →	+0.544	+0.185	<.001	<.001	3	3
GBM	MFSD1 →	+0.319	+0.139	.009	.003	3	3
GBM	DAB2 →	+0.590	+0.152	.001	.001	3	3
LSCC	CD109 →	+0.788	+0.124	.004	.007	3	3
LSCC	PELI1 →	+0.636	+0.158	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035493 vs SRPX — HNSC

Explore this scatter interactively →