Cellular response to interferon-beta

Across TCGA patient cohorts, RNA activity of the Cellular response to interferon-beta pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP4, NMI, and OAS2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to interferon-beta activity versus GBP4 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GBP4 →	+0.645	+0.081	<.001	<.001	3	10
BRCA	NMI →	+0.648	+0.068	<.001	<.001	3	10
HNSC	OAS2 →	+0.772	+0.068	<.001	.003	3	10
BRCA	PSMB10 →	+0.645	+0.061	<.001	<.001	3	10
LSCC	PSMB6 →	-0.425	-0.104	<.001	<.001	3	10
BRCA	PSME2 →	+0.408	+0.051	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035458 vs GBP4 — GBM

Explore this scatter interactively →