Cellular response to interferon-beta

Across TCGA patient cohorts, RNA activity of the Cellular response to interferon-beta pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFIH1, UBE2L6, and BATF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to interferon-beta activity versus IFIH1 in GBM (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IFIH1 →	+0.814	+0.199	.001	<.001	3	5
HNSC	UBE2L6 →	+1.012	+0.151	.003	.001	3	5
HNSC	BATF2 →	+0.987	+0.127	<.001	<.001	3	5
HNSC	TAP1 →	+0.940	+0.212	<.001	<.001	3	5
HNSC	IFI35 →	+0.957	+0.129	.002	.007	3	5
HNSC	PSMB9 →	+0.829	+0.174	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035458 vs IFIH1 — GBM

Explore this scatter interactively →