Cellular response to interferon-beta

Across TCGA cell cohorts, RNA activity of the Cellular response to interferon-beta pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIF1L, H2AC16, and GEMIN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AIF1L grouped by Cellular response to interferon-beta-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AIF1L →	+1.562	+0.883	.005	.006	3	4
BREAST	H2AC16 →	+0.741	+0.751	.001	.002	3	4
PANCREAS	GEMIN2 →	+0.543	+0.961	.002	.002	3	4
LUNG_SCLC	TLE4 →	-3.140	-1.609	.006	<.001	3	3
SKIN	FTH1 →	-1.130	-0.927	<.001	.004	3	3
SOFT_TISSUE	VNN2 →	-0.193	-1.306	.004	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AIF1L by Cellular response to interferon-beta activity — BLOOD_Leukemia

Explore this box plot interactively →