Cellular response to interferon-beta

Across TCGA cell cohorts, RNA activity of the Cellular response to interferon-beta pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSANTD4, SP140L, and BECN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to interferon-beta activity versus MSANTD4 in KIDNEY (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MSANTD4 →	+0.788	+0.274	.002	.005	3	6
BLOOD_Lymphoma	SP140L →	+1.309	+0.224	<.001	<.001	3	6
BLOOD_Lymphoma	BECN1 →	+0.660	+0.222	.001	<.001	3	5
BLOOD_Lymphoma	HADHB →	+0.949	+0.297	.004	.004	3	5
LIVER	RPUSD4 →	+0.873	+0.298	.002	.008	3	5
BLOOD_Lymphoma	HELB →	+0.857	+0.219	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035458 vs MSANTD4 — KIDNEY

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