Response to interferon-beta

Across TCGA patient cohorts, RNA activity of the Response to interferon-beta pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIGLEC1, SP110_S244, and STAT2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interferon-beta activity versus SIGLEC1 in GBM (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SIGLEC1 →	+0.535	+0.083	<.001	<.001	3	10
LSCC	SP110_S244 →	+0.687	+0.105	<.001	<.001	3	10
GBM	STAT2 →	+0.485	+0.076	<.001	<.001	3	10
BRCA	TRIM22 →	+0.594	+0.050	<.001	<.001	3	10
GBM	CARD16 →	+0.965	+0.104	<.001	<.001	3	10
HNSC	CMPK2 →	+0.711	+0.092	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035456 vs SIGLEC1 — GBM

Explore this scatter interactively →