Response to interferon-beta

Across TCGA cell cohorts, RNA activity of the Response to interferon-beta pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKT3, TONSL, and PA2G4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AKT3 grouped by Response to interferon-beta-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AKT3 →	-2.460	-1.290	<.001	.002	2	5
BLOOD_Myeloma	TONSL →	+1.384	+1.682	.008	.002	3	4
CNS	PA2G4 →	+0.643	+1.046	.003	.002	3	4
BREAST	GRIN2D →	-0.841	-0.586	.007	.007	3	4
BREAST	HAUS8 →	+0.850	+0.875	.007	.006	3	4
BREAST	OAZ3 →	+1.152	+0.876	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AKT3 by Response to interferon-beta activity — BONE

Explore this box plot interactively →