Response to interferon-beta

Across TCGA cell cohorts, RNA activity of the Response to interferon-beta pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPA4L, BAG3, and PNO1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interferon-beta activity versus HSPA4L in BLOOD_Lymphoma (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HSPA4L →	+1.184	+0.233	.001	<.001	3	6
BLOOD_Lymphoma	BAG3 →	+1.271	+0.188	.005	.003	3	5
LUNG_NSCLC_LUSC	PNO1 →	+0.641	+0.356	.002	.003	3	5
BLOOD_Lymphoma	FAH →	+1.119	+0.246	<.001	<.001	2	6
BLOOD_Lymphoma	SUOX →	+2.152	+0.227	<.001	<.001	3	5
BLOOD_Lymphoma	ZC3H12C →	+1.490	+0.228	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035456 vs HSPA4L — BLOOD_Lymphoma

Explore this scatter interactively →