Copper ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Copper ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARRB2, SLC8A1, and PALM2AKAP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Copper ion transmembrane transport activity versus ARRB2 in LSCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARRB2 →	-0.389	-0.590	<.001	<.001	3	4
LSCC	SLC8A1 →	-0.429	-0.497	.003	.002	3	4
LUAD	PALM2AKAP2 →	-0.364	-0.570	.003	.003	3	4
LSCC	PALD1 →	-0.572	-0.750	<.001	<.001	3	3
LSCC	DDX25 →	-0.289	-0.351	.004	.007	3	3
LSCC	NEURL2 →	-0.323	-0.548	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035434 vs ARRB2 — LSCC

Explore this scatter interactively →