Roundabout signaling pathway

Across TCGA cell cohorts, RNA activity of the Roundabout signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHMP1A, BSDC1, and PPP6C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHMP1A grouped by Roundabout signaling pathway-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CHMP1A →	+1.003	+1.303	.002	.006	3	3
BLOOD_Leukemia	BSDC1 →	+1.051	+1.064	.003	.009	3	3
CNS	PPP6C →	-0.387	-0.934	.002	.003	3	3
CNS	CCDC191 →	+0.742	+0.744	.009	.007	3	3
CNS	CARNS1 →	+0.267	+0.994	.008	.002	2	4
LUNG_NSCLC_LUAD	ABLIM2 →	-0.603	-0.685	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHMP1A by Roundabout signaling pathway activity — OESOPHAGUS

Explore this box plot interactively →