Regulation of peroxisome proliferator activated receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of peroxisome proliferator activated receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGDH, DNAH5, and RPE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peroxisome proliferator activated receptor signaling pathway activity versus UGDH in URINARY_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	UGDH →	+1.226	+2.159	.001	<.001	3	5
LIVER	DNAH5 →	-0.675	-1.585	.002	.002	3	5
LUNG_NSCLC_LUSC	RPE →	+0.782	+2.153	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	DEPTOR →	+0.581	+1.306	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	MFF →	+0.876	+1.992	.001	<.001	3	4
OVARY	TYMS →	+1.347	+1.173	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035358 vs UGDH — URINARY_TRACT

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