Regulation of peroxisome proliferator activated receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of peroxisome proliferator activated receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FABP5, PFDN6, and NUDC, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peroxisome proliferator activated receptor signaling pathway activity versus FABP5 in URINARY_TRACT (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FABP5 →	+4.083	+1.918	<.001	<.001	3	15
LUNG_NSCLC_LUSC	PFDN6 →	+1.882	+1.776	.009	.009	3	15
LUNG_NSCLC_LUSC	NUDC →	+1.987	+1.736	.007	.001	3	14
LUNG_NSCLC_LUSC	PFDN2 →	+2.872	+1.836	.003	.007	3	14
URINARY_TRACT	NME1 →	+2.467	+1.793	<.001	.008	3	14
SKIN	UBR4 →	+0.937	+0.797	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035358 vs FABP5 — URINARY_TRACT

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