Intracellular triglyceride homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular triglyceride homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMOD2, UBE2G1, and DIP2C, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular triglyceride homeostasis activity versus TMOD2 in GBM (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMOD2 →	+0.434	+0.066	<.001	<.001	3	6
COAD	UBE2G1 →	-0.327	-0.063	<.001	<.001	3	6
COAD	DIP2C →	+0.388	+0.046	.003	.007	2	7
GBM	DNM1 →	+0.735	+0.073	<.001	<.001	3	6
GBM	MAP1A →	+0.532	+0.075	<.001	<.001	3	6
OV	COL8A1 →	+1.004	+0.066	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035356 vs TMOD2 — GBM

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