Intracellular triglyceride homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular triglyceride homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFRP2, GDI1, and FGD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular triglyceride homeostasis activity versus SFRP2 in OV (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SFRP2 →	+3.039	+0.165	<.001	.003	3	4
OV	GDI1 →	+0.561	+0.147	.004	.007	3	4
CCRCC	FGD1 →	+0.341	+0.136	.001	.004	3	4
OV	ITGA11 →	+1.359	+0.135	<.001	.008	3	3
UCEC	VWA3B →	-1.327	-0.704	<.001	.002	3	3
OV	ALPK2 →	+1.003	+0.162	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035356 vs SFRP2 — OV

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