Intracellular triglyceride homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular triglyceride homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP2, TGFBI, and PIK3C2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GBP2 grouped by Intracellular triglyceride homeostasis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GBP2 →	-1.616	-1.035	.004	.002	3	4
STOMACH	TGFBI →	-4.945	-1.431	.002	.007	2	5
BLOOD_Leukemia	PIK3C2B →	+1.785	+0.879	.002	.009	3	4
PANCREAS	GIGYF1 →	+0.632	+1.012	.001	.006	3	4
BONE	PHC1 →	+1.352	+1.618	.003	<.001	3	4
BONE	SEC13 →	-1.312	-2.025	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GBP2 by Intracellular triglyceride homeostasis activity — SKIN

Explore this box plot interactively →