Intracellular triglyceride homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular triglyceride homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF574, ZDHHC13, and FUNDC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular triglyceride homeostasis activity versus ZNF574 in PANCREAS (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZNF574 →	+0.949	+0.378	.001	.005	3	3
PANCREAS	ZDHHC13 →	+1.215	+0.378	.003	.005	3	3
LUNG_SCLC	FUNDC2 →	+1.100	+1.164	<.001	<.001	3	3
BLOOD_Leukemia	SUV39H1 →	+0.685	+0.543	<.001	.008	2	3
LUNG_SCLC	CETN2 →	+1.593	+1.311	.001	.003	3	2
LUNG_SCLC	OXA1L →	-0.799	-1.256	.006	.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035356 vs ZNF574 — PANCREAS

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