Long-chain fatty-acyl-CoA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Long-chain fatty-acyl-CoA biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYAP1, VDAC1, and QKI, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty-acyl-CoA biosynthetic process activity versus SYAP1 in OV (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SYAP1 →	+0.339	+0.031	.003	.008	3	6
UCEC	VDAC1 →	+0.448	+0.055	<.001	.002	3	6
UCEC	QKI →	-0.357	-0.061	<.001	.001	3	6
GBM	FKBP7 →	-0.409	-0.043	<.001	<.001	3	6
BRCA	AGO1 →	-0.244	-0.041	<.001	<.001	3	5
GBM	ATP1B1 →	+0.510	+0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035338 vs SYAP1 — OV

Explore this scatter interactively →