Long-chain fatty-acyl-CoA biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Long-chain fatty-acyl-CoA biosynthetic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher Long-chain fatty-acyl-CoA biosynthetic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and SKCM, show the opposite pattern, with higher activity associated with better survival.

BRCA, CHOL, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Quartile	III,IV	0.709	0.367	.004	59	view →
CHOL	OS	Tertile	II,III,IV	0.284	1.000	<.001	41	view →
SKCM	OS	Tertile	II,III,IV	0.837	0.641	<.001	40	view →
KIRP	DFS	Tertile	All	0.804	1.000	.004	36	view →
HNSC	OS	Tertile	II,III,IV	0.255	0.502	.007	23	view →
LUSC	DFS	Quartile	III,IV	0.161	0.993	.001	22	view →
COAD	DFS	Tertile	IV	0.640	0.328	.001	21	view →
SCLC	DFS	Quartile	II,III,IV	0.156	0.806	.024	20	view →
UVM	OS	Median	All	0.932	0.770	.017	16	view →
LUAD	DFS	Median	IV	0.640	0.352	.021	15	view →
PRAD	DFS	Tertile	All	0.937	0.861	.013	14	view →
THYM	DFS	Median	II,III,IV	0.801	0.952	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0035338–BRCA (OS)

Open the BRCA breakdown →