Long-chain fatty-acyl-CoA biosynthetic process

Across TCGA patient cohorts, RNA activity of the Long-chain fatty-acyl-CoA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H14, PLEKHG7, and OAS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty-acyl-CoA biosynthetic process activity versus ZC3H14 in CCRCC (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZC3H14 →	-0.314	-0.155	<.001	<.001	3	4
LSCC	PLEKHG7 →	+0.771	+0.146	<.001	<.001	3	4
OV	OAS2 →	+1.023	+0.140	.003	.006	3	4
LSCC	OAS1 →	+0.569	+0.105	.003	.006	3	4
BRCA	FKTN →	-0.374	-0.214	.003	.005	3	4
CCRCC	CABP1 →	-0.741	-0.137	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035338 vs ZC3H14 — CCRCC

Explore this scatter interactively →