Long-chain fatty-acyl-CoA biosynthetic process

Across TCGA cell cohorts, RNA activity of the Long-chain fatty-acyl-CoA biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPC2, FURIN, and ACVR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Long-chain fatty-acyl-CoA biosynthetic process activity versus NPC2 in KIDNEY (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NPC2 →	+1.048	+0.157	.008	.007	2	6
BLOOD_Lymphoma	FURIN →	+3.018	+1.495	.003	<.001	3	5
BLOOD_Lymphoma	ACVR1 →	+1.433	+0.821	.005	.007	3	4
BLOOD_Lymphoma	CD63 →	+1.976	+1.415	<.001	<.001	3	4
BLOOD_Lymphoma	PHLDB1 →	+1.621	+1.201	.003	.004	3	4
PANCREAS	ENDOD1 →	+1.239	+0.227	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035338 vs NPC2 — KIDNEY

Explore this scatter interactively →