Fatty-acyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Fatty-acyl-CoA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRAP1, PPFIBP1, and TPM4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty-acyl-CoA metabolic process activity versus TRAP1 in HNSC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAP1 →	+0.285	+0.052	.005	.001	2	8
HNSC	PPFIBP1 →	-0.292	-0.041	.002	.007	3	7
CCRCC	TPM4 →	-0.337	-0.032	.003	.003	3	7
COAD	GTPBP10 →	+0.399	+0.025	<.001	<.001	3	7
LSCC	UNG →	+0.338	+0.026	.005	.001	3	6
LSCC	CRTAP →	-0.445	-0.032	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035337 vs TRAP1 — HNSC

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