Long-chain fatty-acyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Long-chain fatty-acyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC34, NYAP1, and PAIP2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC34 grouped by Long-chain fatty-acyl-CoA metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CDC34 →	-0.711	-1.410	.001	.004	3	4
LARGE_INTESTINE	NYAP1 →	+0.614	+1.218	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PAIP2B →	-0.845	-1.514	.003	<.001	3	4
BONE	NIPA1 →	+0.806	+1.551	.007	.002	2	5
BLOOD_Lymphoma	LRTOMT →	+0.947	+2.099	.009	<.001	3	3
LIVER	NDEL1 →	+0.670	+1.325	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC34 by Long-chain fatty-acyl-CoA metabolic process activity — LUNG_SCLC

Explore this box plot interactively →