Peptidyl-tyrosine dephosphorylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-tyrosine dephosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MBOAT1, TTC39B, and ABCC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-tyrosine dephosphorylation activity versus MBOAT1 in CNS (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MBOAT1 →	-0.653	-0.965	.006	.007	3	5
LUNG_NSCLC_LUSC	TTC39B →	-1.504	-1.286	.002	.002	3	4
URINARY_TRACT	ABCC5 →	-2.127	-1.682	.005	<.001	3	4
URINARY_TRACT	TMEM117 →	-1.051	-1.314	.006	.003	3	4
URINARY_TRACT	MEIS1 →	-1.691	-1.644	.004	<.001	3	4
URINARY_TRACT	ZFP36L2 →	-2.481	-1.429	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035335 vs MBOAT1 — CNS

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