Positive regulation of hippo signaling

Across TCGA patient cohorts, RNA activity of the Positive regulation of hippo signaling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLG5, MYOF, and GFRA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hippo signaling activity versus DLG5 in BRCA (Pearson r = 0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DLG5 →	+1.268	+0.573	<.001	.002	3	5
BRCA	MYOF →	+0.682	+0.431	.001	.001	3	4
BRCA	GFRA3 →	-0.732	-0.400	<.001	.008	3	4
GBM	MIR4768 →	+1.161	+0.405	<.001	.005	3	4
UCEC	KIAA1217 →	+0.377	+0.363	.006	.005	3	4
UCEC	CD44 →	+0.759	+0.496	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035332 vs DLG5 — BRCA

Explore this scatter interactively →