Negative regulation of hippo signaling

Across TCGA patient cohorts, RNA activity of the Negative regulation of hippo signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGV, KLRD1, and AJUBA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hippo signaling activity versus PIGV in LUAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PIGV →	+0.370	+0.298	<.001	.002	3	4
UCEC	KLRD1 →	-0.609	-0.626	.001	<.001	3	4
HNSC	AJUBA →	+0.641	+0.295	.001	.002	3	4
PDAC	ZC3H14 →	+0.273	+0.205	<.001	<.001	3	3
PDAC	TMEM106B →	+0.431	+0.247	<.001	<.001	3	3
PDAC	HIPK3 →	+0.269	+0.167	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035331 vs PIGV — LUAD

Explore this scatter interactively →