Negative regulation of hippo signaling

Across TCGA cell cohorts, RNA activity of the Negative regulation of hippo signaling pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS13, LRRC73, and PRCP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHRS13 grouped by Negative regulation of hippo signaling-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DHRS13 →	+1.636	+0.219	<.001	<.001	3	5
BREAST	LRRC73 →	+0.712	+0.174	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PRCP →	-1.585	-0.185	.002	.003	3	4
BREAST	ZNF646 →	+0.739	+0.126	<.001	<.001	3	4
BREAST	PIK3C2B →	+1.362	+0.144	.001	.002	3	4
BREAST	TONSL →	+1.405	+0.177	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHRS13 by Negative regulation of hippo signaling activity — BREAST

Explore this box plot interactively →