Negative regulation of hippo signaling

Across TCGA cell cohorts, RNA activity of the Negative regulation of hippo signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPI1P2, ZNF90, and IL5RA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TPI1P2 grouped by Negative regulation of hippo signaling-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TPI1P2 →	-0.130	-0.756	<.001	<.001	3	4
BLOOD_Lymphoma	ZNF90 →	+0.368	+0.123	.007	.003	3	4
BLOOD_Leukemia	IL5RA →	+0.293	+0.137	<.001	.005	3	3
LARGE_INTESTINE	ITGA11 →	-0.129	-0.738	.001	.002	3	3
CNS	PDCL2 →	-0.144	-1.096	.004	.001	3	3
LUNG_NSCLC_LUSC	CDIP1 →	+0.169	+1.509	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TPI1P2 by Negative regulation of hippo signaling activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →