Regulation of hippo signaling

Across TCGA patient cohorts, RNA activity of the Regulation of hippo signaling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD7, SSPN, and PYGO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hippo signaling activity versus CD7 in BRCA (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD7 →	-0.979	-0.376	<.001	.005	3	4
LUAD	SSPN →	+0.507	+0.350	.001	.001	3	3
LUAD	PYGO1 →	+0.467	+0.237	.003	.002	2	4
LUAD	MYO6 →	+0.580	+0.298	.001	.001	3	3
LUAD	C14orf132 →	+0.585	+0.281	.005	.001	3	3
LUAD	NR2F2-AS1 →	+0.454	+0.306	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035330 vs CD7 — BRCA

Explore this scatter interactively →