Regulation of hippo signaling

Across TCGA cell cohorts, RNA activity of the Regulation of hippo signaling pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CREB3L4, LRRC8B, and TONSL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CREB3L4 grouped by Regulation of hippo signaling-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CREB3L4 →	+0.924	+0.262	.003	.005	3	5
UPPER_AERODIGESTIVE_TRACT	LRRC8B →	+1.363	+0.325	<.001	.006	2	6
BREAST	TONSL →	+1.202	+0.214	<.001	<.001	3	5
LARGE_INTESTINE	ELL3 →	+1.736	+0.205	.002	.003	2	5
BLOOD_Leukemia	TMEM256 →	+1.321	+0.191	<.001	.009	3	4
URINARY_TRACT	KHDC1 →	-2.240	-0.338	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CREB3L4 by Regulation of hippo signaling activity — PANCREAS

Explore this box plot interactively →