Regulation of hippo signaling

Across TCGA cell cohorts, RNA activity of the Regulation of hippo signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OXA1L, KCNQ1, and PSMC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OXA1L grouped by Regulation of hippo signaling-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OXA1L →	-0.340	-0.082	.004	<.001	3	5
KIDNEY	KCNQ1 →	-0.261	-0.085	.002	.009	3	5
OVARY	PSMC1 →	-0.386	-0.060	.003	.003	3	5
LUNG_SCLC	IMPG2 →	-0.144	-0.091	.004	<.001	3	5
CNS	CCNK →	-0.410	-0.085	.001	<.001	3	4
LUNG_NSCLC_LUAD	TLN1 →	+0.347	+0.080	.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OXA1L by Regulation of hippo signaling activity — LUNG_SCLC

Explore this box plot interactively →