Regulation of hippo signaling

Across TCGA cell cohorts, RNA activity of the Regulation of hippo signaling pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC41A1, ABL2, and CBL, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hippo signaling activity versus SLC41A1 in LIVER (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC41A1 →	+1.449	+0.090	<.001	<.001	3	17
STOMACH	ABL2 →	+2.021	+0.092	<.001	.002	3	17
PANCREAS	CBL →	+1.011	+0.072	<.001	.001	3	17
STOMACH	MYO9A →	+1.202	+0.124	.001	<.001	3	17
BONE	NFAT5 →	+1.287	+0.113	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	RNF216 →	+0.995	+0.072	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035330 vs SLC41A1 — LIVER

Explore this scatter interactively →