Regulation of hippo signaling

Across TCGA cell cohorts, RNA activity of the Regulation of hippo signaling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAK2, KCNK1, and GLOD4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hippo signaling activity versus TRAK2 in BLOOD_Myeloma (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TRAK2 →	-0.890	-0.235	.004	.001	3	4
BLOOD_Myeloma	KCNK1 →	-2.839	-0.231	.009	.001	3	4
LIVER	GLOD4 →	+0.690	+0.232	.004	.001	1	6
BLOOD_Lymphoma	AGRN →	-2.364	-0.177	.001	.002	3	4
STOMACH	CORO7 →	+0.964	+0.187	<.001	.002	2	5
STOMACH	PTHLH →	-2.793	-0.180	.005	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035330 vs TRAK2 — BLOOD_Myeloma

Explore this scatter interactively →