Hippo signaling

Across TCGA patient cohorts, RNA activity of the Hippo signaling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SSC5D, TLN2, and FLNA, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hippo signaling activity versus SSC5D in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SSC5D →	+0.799	+0.032	<.001	.001	3	9
OV	TLN2 →	+0.480	+0.043	.002	.005	3	9
BRCA	FLNA →	+0.464	+0.038	.001	<.001	3	9
BRCA	KANK2 →	+0.547	+0.049	<.001	<.001	3	9
LSCC	PRKG1 →	+0.522	+0.057	<.001	<.001	3	9
BRCA	RSU1 →	+0.369	+0.031	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035329 vs SSC5D — BRCA

Explore this scatter interactively →