Hippo signaling

Across TCGA patient cohorts, RNA activity of the Hippo signaling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDH3, LAYN, and TES, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hippo signaling activity versus CDH3 in OV (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDH3 →	+1.258	+0.286	<.001	.005	3	5
LUAD	LAYN →	+0.581	+0.410	.001	.002	3	5
BRCA	TES →	+0.668	+0.451	.004	.006	3	4
UCEC	MYO1H →	+0.304	+0.685	.006	.008	3	4
GBM	EVA1A →	+0.923	+0.640	.002	.001	3	4
GBM	BICC1 →	+0.804	+0.572	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035329 vs CDH3 — OV

Explore this scatter interactively →