Hair cell differentiation

Across TCGA patient cohorts, RNA activity of the Hair cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINA7, EIF3G, and A1BG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hair cell differentiation activity versus SERPINA7 in OV (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINA7 →	+0.399	+0.028	.001	<.001	3	5
LSCC	EIF3G →	-0.142	-0.035	.001	<.001	3	5
CCRCC	A1BG →	+0.296	+0.030	.006	.003	3	4
CCRCC	RPL27 →	-0.241	-0.037	.001	.003	3	4
CCRCC	RPL5 →	-0.166	-0.039	.002	.002	3	4
CCRCC	RPS15 →	-0.167	-0.040	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035315 vs SERPINA7 — OV

Explore this scatter interactively →