"Wound healing, spreading of epidermal cells"

Across TCGA patient cohorts, RNA activity of the "Wound healing, spreading of epidermal cells" pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POGLUT2, NTM, and SNAI2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Wound healing, spreading of epidermal cells" activity versus POGLUT2 in LUAD (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	POGLUT2 →	+0.284	+0.559	.006	<.001	3	5
COAD	NTM →	+0.903	+0.459	.001	.004	2	6
LUAD	SNAI2 →	+0.516	+0.678	.002	<.001	3	5
LUAD	PDLIM7 →	+0.422	+0.529	.001	.006	3	5
LSCC	FUT11 →	+0.602	+0.879	<.001	<.001	3	5
COAD	SUGCT →	+0.781	+0.525	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035313 vs POGLUT2 — LUAD

Explore this scatter interactively →