"Wound healing, spreading of epidermal cells"

Across TCGA cell cohorts, RNA activity of the "Wound healing, spreading of epidermal cells" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL6A1, ZSCAN9, and PLD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COL6A1 grouped by "Wound healing, spreading of epidermal cells"-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	COL6A1 →	+3.355	+1.452	<.001	.005	3	6
LIVER	ZSCAN9 →	+0.808	+1.452	.002	.006	3	5
STOMACH	PLD3 →	+0.757	+1.049	.009	.007	3	5
LARGE_INTESTINE	TNFRSF12A →	+1.873	+1.495	<.001	<.001	2	6
BONE	NIN →	+1.360	+1.664	.001	<.001	3	5
BONE	C4orf3 →	+0.953	+1.481	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COL6A1 by "Wound healing, spreading of epidermal cells" activity — LIVER

Explore this box plot interactively →