"Wound healing, spreading of epidermal cells"

Across TCGA cell cohorts, RNA activity of the "Wound healing, spreading of epidermal cells" pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLPP2, DSG2, and ADCK5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHLPP2 grouped by "Wound healing, spreading of epidermal cells"-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PHLPP2 →	+0.173	+0.208	.002	.001	3	4
BREAST	DSG2 →	-0.147	-0.168	.007	.002	3	4
URINARY_TRACT	ADCK5 →	-0.203	-0.273	.001	.003	3	4
OVARY	SSH3 →	-0.161	-0.151	.008	.002	3	4
LUNG_NSCLC_LUSC	SEC11C →	-0.195	-0.226	.004	.005	2	5
LUNG_NSCLC_LUSC	CAV3 →	-0.239	-0.230	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHLPP2 by "Wound healing, spreading of epidermal cells" activity — URINARY_TRACT

Explore this box plot interactively →