"Wound healing, spreading of epidermal cells"

Across TCGA cell cohorts, RNA activity of the "Wound healing, spreading of epidermal cells" pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LUM, ZEB1, and ITGB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Wound healing, spreading of epidermal cells" activity versus LUM in CNS (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LUM →	+3.811	+0.290	<.001	<.001	3	7
BONE	ZEB1 →	+2.091	+0.385	.006	.005	3	6
BONE	ITGB1 →	+1.932	+0.482	<.001	<.001	3	6
BONE	EFR3A →	+2.388	+0.482	<.001	<.001	3	6
BONE	PIGK →	+2.146	+0.480	.002	.005	3	6
SOFT_TISSUE	CCDC50 →	+2.055	+0.393	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035313 vs LUM — CNS

Explore this scatter interactively →