Positive regulation of dephosphorylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of dephosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPM3, HOXB-AS3, and RAB17, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TPM3 grouped by Positive regulation of dephosphorylation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TPM3 →	+0.190	+0.113	.009	<.001	3	3
BLOOD_Leukemia	HOXB-AS3 →	-0.246	-1.413	.009	.003	3	3
LUNG_NSCLC_LUAD	RAB17 →	+0.202	+0.509	<.001	.003	3	2
LUNG_NSCLC_LUAD	STON1 →	-0.094	-0.323	.007	.004	3	2
UPPER_AERODIGESTIVE_TRACT	NRBP1 →	-0.247	-0.105	.003	.002	3	2
UPPER_AERODIGESTIVE_TRACT	ACADL →	+0.258	+0.152	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TPM3 by Positive regulation of dephosphorylation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →